Glycogen Regulation in Isolated Perfused Near Term Monkey Liver
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Imatinib metabolism and disposition in isolated rat perfused liver
Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...
متن کاملThe Isolated Perfused Bovine Liver
1. A procedure is described for surgically isolating and artificially perfusing the liver of the young bovine. Heparinized autogenous blood from the hepatectomized animal diluted with Krebs-Ringer-bicarbonate solution is employed as the perfusate. 2. This preparation has been satisfactorily reproducible in this laboratory in more than 90 separate sequential perfusions. Absence of a sensitive he...
متن کاملThe Effects of Glucose and Fructose on Glycogen Metabolism in the Isolated Perfused Rat Liver
Glycogen metabolism is considered to be regulated by the activities of the a forms of glycogen synthase and phosphorylase. Among other factors, the concentration of circulating blood glucose controls the activities of these two enzymes. It has been shown in experiments in oivo (De Wulf & Hers, 1967; Stalmans et al., 1974), isolated perfused liver (Buschiazzo et al., 1970; Glinsmann et al., 1970...
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Conversion of phosphorylase b to a has been considered to be a major mechanism for increasing phosphorylase activity and glycogenolysis. Certain observations have suggested that other factors are also involved (1, 2). In particular, anoxia produced faster glycogenolysis but less conversion of phosphorylase b to a than did glucagon in the perfused rat heart (1). Faster glycogenolysis in the anox...
متن کاملThe isolated perfused rat liver.
The disposition of mefloquine has been investigated in the isolated perfused rat liver (IPRL) preparation after the administration of [C]mefloquine HCI (3.8 mg, 4 1 Ci, quinoline ring labeled). Mefloquine underwent avid hepatic uptake within 10 min of dosing. Also at this point, hepatic oxygen consumption was reduced markedly in four of the six IPRL preparations, but was restored completely by ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1976
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197601000-00010